Faculty

Sandeep Nathan, MD MSC

  • Professor of Medicine
  • Clinical Interests: Acute Coronary Syndromes, Acute myocardial infarction (heart attacks), Antiplatelet Therapies, Coronary Artery Disease, Intravascular Ultrasound, Peripheral Arterial Disease
  • Websites: Research Network Profile
  • Contact: sandeepnathan@uchicago.edu

Sandeep Nathan, MD, is a highly skilled cardiologist who specializes in interventional cardiovascular procedures. Dr. Nathan performs a wide range of coronary and peripheral vascular procedures for the diagnosis and treatment of cardiovascular disease, including balloon angioplasty, stenting, atherectomy, thrombectomy, cryoplasty and intravascular ultrasound imaging.



He is one of few interventional cardiologists who routinely perform transradial angiography and intervention, a less invasive alternative to traditional approaches. Transradial angiography uses an artery in the wrist, instead of the leg, as the entryway for diagnostic imaging and therapeutic procedures, such as angioplasty and stenting. This technique offers fewer risks and greater advantages, including increased patient comfort and immediate mobility following the procedure. Additionally, Dr. Nathan is a general cardiologist who treats patients with coronary artery disease (CAD), peripheral arterial disease (PAD) and risk factors for heart disease.



His research interests include platelet biology, interventional device therapies, intravascular imaging, and the use of antiplatelet and antithrombotic therapies (blood thinners) in the management of acute coronary syndromes and heart attacks. Dr. Nathan holds a master's degree in clinical research. He currently serves as a principal investigator or co-investigator on several clinical trials evaluating: new antiplatelet therapies in patients with acute coronary syndromes; novel stents for the treatment of coronary artery disease; and clinical outcomes in patients who have had percutaneous coronary interventions (angioplasty/stent) and heart attacks.

Future Directions in Temporary Mechanical Circulatory Support for Cardiogenic Shock: Novel Devices and Evolving Therapeutic Paradigms.
Future Directions in Temporary Mechanical Circulatory Support for Cardiogenic Shock: Novel Devices and Evolving Therapeutic Paradigms. Interv Cardiol Clin. 2026 Jul; 15(3):491-510.
PMID: 42209079

The Challenge of Cardiogenic Shock Transfers: The Devil in the Details.
The Challenge of Cardiogenic Shock Transfers: The Devil in the Details. J Soc Cardiovasc Angiogr Interv. 2026 May; 5(5):105325.
PMID: 42183118

Dark sides and warm rides: Is cardiopulmonary bypass necessary for grafting posterior wall targets in robotic totally endoscopic coronary bypass?
Dark sides and warm rides: Is cardiopulmonary bypass necessary for grafting posterior wall targets in robotic totally endoscopic coronary bypass? JTCVS Tech. 2026 Jun; 37:102310.
PMID: 42292120

Hybrid Revascularization With Robotic Totally Endoscopic Coronary Bypass and Stents: What Are the Outcomes When The Stent Does Not Happen?
Hybrid Revascularization With Robotic Totally Endoscopic Coronary Bypass and Stents: What Are the Outcomes When The Stent Does Not Happen? Ann Thorac Surg. 2026 Aug; 122(2):351-358.
PMID: 41713763

Best Practices for Use of the Super High Pressure OPN Balloon.
Best Practices for Use of the Super High Pressure OPN Balloon. Am J Cardiol. 2026 Apr 15; 265:32-41.
PMID: 41633442

Shortened dual antiplatelet therapy duration after percutaneous patent foramen ovale and atrial septal defect closure.
Shortened dual antiplatelet therapy duration after percutaneous patent foramen ovale and atrial septal defect closure. J Invasive Cardiol. 2025 Dec; 37(12).
PMID: 40815602

SCAI Door to Lactate Clearance (SCAI DLC) Cardiogenic Shock Initiative: Definition, Hypothesis, and Call to Action.
SCAI Door to Lactate Clearance (SCAI DLC) Cardiogenic Shock Initiative: Definition, Hypothesis, and Call to Action. J Soc Cardiovasc Angiogr Interv. 2025 Nov; 4(11):103996.
PMID: 41324047

Impact of comorbidity burden on outcome in patients with cardiogenic shock: A Cardiogenic Shock Working Group analysis.
Impact of comorbidity burden on outcome in patients with cardiogenic shock: A Cardiogenic Shock Working Group analysis. Eur J Heart Fail. 2025 Nov; 27(11):2244-2258.
PMID: 40956069

Comparison of Heart Failure Cardiogenic Shock Patients with Axillary and Femoral Intra-aortic Balloon Pump: Cardiogenic Shock Working Group report.
Comparison of Heart Failure Cardiogenic Shock Patients with Axillary and Femoral Intra-aortic Balloon Pump: Cardiogenic Shock Working Group report. J Card Fail. 2026 02; 32(2):394-405.
PMID: 40846302

Expanding the Role of Drug-Coated Balloons in Contemporary Percutaneous Coronary Intervention: Start of the Next Revolution or Just One More Weapon in a Growing Arsenal?
Expanding the Role of Drug-Coated Balloons in Contemporary Percutaneous Coronary Intervention: Start of the Next Revolution or Just One More Weapon in a Growing Arsenal? J Am Heart Assoc. 2025 Jun 03; 14(11):e042448.
PMID: 40439167

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