Jonathan Grinstein, MD, FACC, is a highly respected cardiologist specializing in the medical management of advanced heart failure. Dr. Grinstein treats patients who require long-term IV medications or continuous infusion pump medications, mechanical circulatory support, such as left ventricular assist devices (LVADs), and heart transplantation.
Along with his devotion to excellent clinical care, Dr. Grinstein is passionate about furthering medicine through research. Dr. Grinstein has evaluated and perfected echocardiographic and computed tomography techniques that noninvasively monitor the pressure and volume inside the heart for patients with an implanted LVAD. This technique allows cardiologists to analyze how well a patient is responding to the device and make necessary adjustments in real time. Additionally, Dr. Grinstein is conducting research to develop a “smart” LVAD that can intuitively adjust its speed based on the physiological needs of the patient. He is also using computational fluid dynamics to study and predict blood flow patterns through the LVAD to maximize device performance.
Dr. Grinstein’s research has been published in several high-impact, peer-reviewed journals, including the Journal of Cardiac Failure, American Society for Artificial Internal Organs Journal, Journal of Heart and Lung Transplantation and JACC: Cardiovascular Imaging.
University of Chicago
Chicago, IL
- Advanced Heart Failure and Cardiac Transplantation
2017
University of Chicago
Chicago, IL
- Cardiovascular Medicine
2016
Brigham and Women's Hospital (Harvard)
Boston, MA
- Internal Medicine
2013
University of Chicago
Chicago, IL
- Medicine
2010
McGill University
Montreal, QC
- Physiology
2006
Concomitant Surgical Procedures and Aspirin Avoidance With Left Ventricular Assist Device Therapy.
Concomitant Surgical Procedures and Aspirin Avoidance With Left Ventricular Assist Device Therapy. JACC Heart Fail. 2025 Apr 09; 102411.
PMID: 40208135
Reviving the Swan: Presenting the Chicago Hemodynamic Forum.
Reviving the Swan: Presenting the Chicago Hemodynamic Forum. Circ Heart Fail. 2025 Apr; 18(4):e012725.
PMID: 40116016
Mitigating Post-operative Right Ventricular Dysfunction After Left Ventricular Assist Device: The RV Protection Study.
Mitigating Post-operative Right Ventricular Dysfunction After Left Ventricular Assist Device: The RV Protection Study. J Card Fail. 2025 Feb 13.
PMID: 39954845
The Virtual Patient Simulator: Using Hemodynamics and the Cardioenergetic Profile to Optimize Heart Failure Care.
The Virtual Patient Simulator: Using Hemodynamics and the Cardioenergetic Profile to Optimize Heart Failure Care. JACC Basic Transl Sci. 2025 Mar; 10(3):259-261.
PMID: 40139863
The Role of Lactate Metabolism in Heart Failure and Cardiogenic Shock: Clinical Insights and Therapeutic Implications.
The Role of Lactate Metabolism in Heart Failure and Cardiogenic Shock: Clinical Insights and Therapeutic Implications. J Card Fail. 2025 Jan 29.
PMID: 39890014
Early and Late Outcomes of Ambulatory Counter Pulsation Devices as a Bridge to Heart Transplantation.
Early and Late Outcomes of Ambulatory Counter Pulsation Devices as a Bridge to Heart Transplantation. Cardiology. 2024 Nov 29; 1-8.
PMID: 40293434
Dynamic assessment of left ventricular coupling and myocardial reserve in patients with cardiogenic shock.
Dynamic assessment of left ventricular coupling and myocardial reserve in patients with cardiogenic shock. Eur Heart J Open. 2024 Sep; 4(5):oeae072.
PMID: 39328214
Galectin-3 as a Prognostic Biomarker of Left Ventricular Assist Device Implantation Outcomes.
Galectin-3 as a Prognostic Biomarker of Left Ventricular Assist Device Implantation Outcomes. ASAIO J. 2025 Feb 01; 71(2):136-142.
PMID: 39088729
Aortic insufficiency in the patient on contemporary durable left ventricular assist device support: A state-of-the-art review on preoperative and postoperative assessment and management.
Aortic insufficiency in the patient on contemporary durable left ventricular assist device support: A state-of-the-art review on preoperative and postoperative assessment and management. J Heart Lung Transplant. 2024 Nov; 43(11):1881-1893.
PMID: 39069161
PREDICT HF: Risk stratification in advanced heart failure using novel hemodynamic parameters.
PREDICT HF: Risk stratification in advanced heart failure using novel hemodynamic parameters. Clin Cardiol. 2024 Jun; 47(6):e24277.
PMID: 38838029
Alpha Omega Alpha
Gold Humanism Honors Society
Finalist, Jay N Cohn Award, Heart Failure Society of America
Member of the Future Leaders in the Growth of Heart Failure Therapies (FLIGHT) Program
MedStar New Investigator Grant
Morton Arnsdorf Award for Best Research
American Society for Clincal Pathology Award for Academic Excellence and Achievement
Dean’s Scholarship for Outstanding Promise in Medicine
Dr. Kathleen Terroux Prize in Physiology