Jonathan Grinstein, MD, FACC, is a highly respected cardiologist specializing in the medical management of advanced heart failure. Dr. Grinstein treats patients who require long-term IV medications or continuous infusion pump medications, mechanical circulatory support, such as left ventricular assist devices (LVADs), and heart transplantation.
Along with his devotion to excellent clinical care, Dr. Grinstein is passionate about furthering medicine through research. Dr. Grinstein has evaluated and perfected echocardiographic and computed tomography techniques that noninvasively monitor the pressure and volume inside the heart for patients with an implanted LVAD. This technique allows cardiologists to analyze how well a patient is responding to the device and make necessary adjustments in real time. Additionally, Dr. Grinstein is conducting research to develop a “smart” LVAD that can intuitively adjust its speed based on the physiological needs of the patient. He is also using computational fluid dynamics to study and predict blood flow patterns through the LVAD to maximize device performance.
Dr. Grinstein’s research has been published in several high-impact, peer-reviewed journals, including the Journal of Cardiac Failure, American Society for Artificial Internal Organs Journal, Journal of Heart and Lung Transplantation and JACC: Cardiovascular Imaging.
University of Chicago
Chicago, IL
- Advanced Heart Failure and Cardiac Transplantation
2017
University of Chicago
Chicago, IL
- Cardiovascular Medicine
2016
Brigham and Women's Hospital (Harvard)
Boston, MA
- Internal Medicine
2013
University of Chicago
Chicago, IL
- Medicine
2010
McGill University
Montreal, QC
- Physiology
2006
Preoperative microaxial flow pump support and post-left ventricular assist device aortic insufficiency: Comprehensive sensitivity analyses confirm a robust and clinically meaningful association.
Preoperative microaxial flow pump support and post-left ventricular assist device aortic insufficiency: Comprehensive sensitivity analyses confirm a robust and clinically meaningful association. J Heart Lung Transplant. 2026 Sep 12.
PMID: 42731648
From Hemodynamics to Energetics: Parameter Identification in a Closed-Loop Model of the Cardiovascular System.
From Hemodynamics to Energetics: Parameter Identification in a Closed-Loop Model of the Cardiovascular System. Int J Numer Method Biomed Eng. 2026 Sep; 42(9):e70214.
PMID: 42785363
Energetic phenotyping in heart failure: From Starling curves to composite variables.
Energetic phenotyping in heart failure: From Starling curves to composite variables. J Biomech. 2026 Sep; 206:113546.
PMID: 42679535
Beyond the mean arterial pressure: Tissue perfusion pressure and end-organ dysfunction after heart transplantation.
Beyond the mean arterial pressure: Tissue perfusion pressure and end-organ dysfunction after heart transplantation. J Heart Lung Transplant. 2026 Aug 19.
PMID: 42570742
Response to: Blumer et al. Letter to the Editor re: Grinstein et al. Aortic insufficiency and right heart failure in patients treated with durable left ventricular assist devices after preoperative support with micro axial flow devices.
Response to: Blumer et al. Letter to the Editor re: Grinstein et al. Aortic insufficiency and right heart failure in patients treated with durable left ventricular assist devices after preoperative support with micro axial flow devices. J Heart Lung Transplant. 2026 Nov; 45(11):1887-1888.
PMID: 42532390
Sodium-Glucose Cotransporter 2 Inhibitor Following Left Ventricular Assist Device Implantation: A Randomized Controlled Trial.
Sodium-Glucose Cotransporter 2 Inhibitor Following Left Ventricular Assist Device Implantation: A Randomized Controlled Trial. JACC Heart Fail. 2026 Jun 30; 103225.
PMID: 42383961
From Hemodynamics to Starling Curves: Applications of Energetic Analysis in Heart Failure Patients.
From Hemodynamics to Starling Curves: Applications of Energetic Analysis in Heart Failure Patients. JACC Heart Fail. 2026 Oct; 14(10):103219.
PMID: 42370867
Aortic insufficiency and right heart failure in patients treated with durable left ventricular assist devices after preoperative support with microaxial flow devices.
Aortic insufficiency and right heart failure in patients treated with durable left ventricular assist devices after preoperative support with microaxial flow devices. J Heart Lung Transplant. 2026 Oct; 45(10):1672-1682.
PMID: 42176716
Resiliency of the right ventricle and long-term outcomes in LVAD recipients bridged with temporary mechanical support.
Resiliency of the right ventricle and long-term outcomes in LVAD recipients bridged with temporary mechanical support. J Heart Lung Transplant. 2026 Sep; 45(9):1492-1494.
PMID: 42114693
The Diastolic Dominance Index: A Bedside Doppler Tool for Aortic Insufficiency in Continuous-Flow Left Ventricular Assist Devices.
The Diastolic Dominance Index: A Bedside Doppler Tool for Aortic Insufficiency in Continuous-Flow Left Ventricular Assist Devices. ASAIO J. 2026 Apr 17.
PMID: 42149687
Alpha Omega Alpha
Gold Humanism Honors Society
Finalist, Jay N Cohn Award, Heart Failure Society of America
Member of the Future Leaders in the Growth of Heart Failure Therapies (FLIGHT) Program
MedStar New Investigator Grant
Morton Arnsdorf Award for Best Research
American Society for Clincal Pathology Award for Academic Excellence and Achievement
Dean’s Scholarship for Outstanding Promise in Medicine
Dr. Kathleen Terroux Prize in Physiology