Dr. Alenghat's laboratory focuses on macrophage biology and the inflammatory processes underlying atherosclerosis. His clinical and academic interests span cardiovascular physiology and pathophysiology, with a particular emphasis on vascular biology and the role of inflammatory pathways in the development of atherosclerotic disease. In addition, Dr. Alenghat has expertise in integrin biology, mechanotransduction, and extracellular matrix biology.
His research aims to uncover fundamental mechanisms that regulate cardiovascular health and disease. A central project in his laboratory investigates how a signaling pathway activated downstream of integrins in macrophages influences atherogenesis and macrophage polarization. The lab employs a range of techniques, including mouse husbandry, tissue sample preparation, immunohistochemistry, and quantitative confocal microscopy.
Dr. Alenghat is also deeply committed to mentoring future physicians and scientists, with a broader goal of promoting health through a deeper understanding of and reduction in cardiovascular disease.
Harvard College
S.B. - Engineering
Harvard Graduate School of Arts & Sciences
Ph.D. - Biophysics
Harvard Medical School
M.D. - Medicine
Brigham & Women's Hospital
- Internal Medicine
Brigham & Women's Hospital
- Cardiovascular Medicine
Management of Atrial Fibrillation.
Management of Atrial Fibrillation. JAMA. 2024 Dec 10; 332(22):1936-1937.
PMID: 39541112
Improved Prognostic Performance of Cardiac Power Output With Right Atrial Pressure: A Subanalysis of the ESCAPE Trial.
Improved Prognostic Performance of Cardiac Power Output With Right Atrial Pressure: A Subanalysis of the ESCAPE Trial. J Card Fail. 2022 05; 28(5):866-869.
PMID: 34774746
The impact of lipid-lowering medications on coronary artery plaque characteristics.
The impact of lipid-lowering medications on coronary artery plaque characteristics. Am J Prev Cardiol. 2021 Dec; 8:100294.
PMID: 34877559
ATTR Cardiomyopathy Meets Multiple Myeloma: The Importance of Cardiac Biopsy.
ATTR Cardiomyopathy Meets Multiple Myeloma: The Importance of Cardiac Biopsy. JACC CardioOncol. 2021 Oct; 3(4):598-601.
PMID: 34729534
A composite metric for predicting benefit from spironolactone in heart failure with preserved ejection fraction.
A composite metric for predicting benefit from spironolactone in heart failure with preserved ejection fraction. ESC Heart Fail. 2021 10; 8(5):3495-3503.
PMID: 34369088
Rapid Exclusion of COVID Infection With the Artificial Intelligence Electrocardiogram.
Rapid Exclusion of COVID Infection With the Artificial Intelligence Electrocardiogram. Mayo Clin Proc. 2021 08; 96(8):2081-2094.
PMID: 34353468
Comparison of semi-automated versus manual quantitative right ventricular assessment in tetralogy of Fallot.
Comparison of semi-automated versus manual quantitative right ventricular assessment in tetralogy of Fallot. Cardiol Young. 2021 Nov; 31(11):1781-1787.
PMID: 33685532
Aortic pulsatility index predicts clinical outcomes in heart failure: a sub-analysis of the ESCAPE trial.
Aortic pulsatility index predicts clinical outcomes in heart failure: a sub-analysis of the ESCAPE trial. ESC Heart Fail. 2021 04; 8(2):1522-1530.
PMID: 33595923
Donor-derived cell-free DNA is associated with cardiac allograft vasculopathy.
Donor-derived cell-free DNA is associated with cardiac allograft vasculopathy. Clin Transplant. 2021 03; 35(3):e14206.
PMID: 33368611
Donor derived cell free DNA is Associated with Cardiac Allograft Vasculopathy.
Holzhauser L, Clerkin KJ, Fujino T, Alenghat FJ, Raikhelkar J, Kim G, Sayer G, Uriel N. Donor derived cell free DNA is Associated with Cardiac Allograft Vasculopathy. Clin Transplant. 2020 Dec 25; e14206.
PMID: 33368611
Fellow of the American College of Cardiology (FACC)
American College of Cardiology
2017
ATVB Young Investigator Travel Award
Council on Arteriosclerosis, Thrombosis, and Vascular Biology
2015
William F. Keating Award for Hypertension & Peripheral Vascular Disease
American College of Cardiology
2013
Thomas W. Smith Fellowship
Brigham & Women's Hospital
2012
AHA/ATVB Travel Award for Young Investigators
American Heart Association
2011
Future Leaders in CV Medical Research Award
Leadership Council for Improving Cardiovascular Care
2010
Laennec Young Clinician Award Finalist
American Heart Association
2009
James Tolbert Shipley Prize
Harvard Medical School
2005
Howard Hughes Predoctoral Fellowship
Howard Hughes Medical Institute
1999
Tau Beta Pi for Excellence in Engineering
Harvard College
1997
Phi Beta Kappa
Harvard College
1996
Detur Prize
Harvard College
1994