Our group focuses on computational approaches to discover and characterize context-specific genetic effects on complex disorders. This includes polygenic methods for gene-environment interaction, gene-gene interaction, and genetic subtypes of disease. We are particularly interested in applications to asthma, major depressive disorder, single cell omics, and cross-population portability of genetic predictions. Our long-term goal is to advance equitable precision treatment by embracing the full diversity of human contexts.
Oxford
PhD - Gen Med and Stats
2016
UChicago
MS - Stats
2012
UChicago
Hon BS - Math
2012
UChicago
BA - Econ
2012
Cell-type-resolved chromatin accessibility in the human intestine identifies complex regulatory programs and clarifies genetic associations in Crohn's disease.
Cell-type-resolved chromatin accessibility in the human intestine identifies complex regulatory programs and clarifies genetic associations in Crohn's disease. medRxiv. 2024 Dec 11.
PMID: 39711713
Polygenic profiles define aspects of clinical heterogeneity in attention deficit hyperactivity disorder.
Polygenic profiles define aspects of clinical heterogeneity in attention deficit hyperactivity disorder. Nat Genet. 2024 Feb; 56(2):234-244.
PMID: 38036780
Phenotype integration improves power and preserves specificity in biobank-based genetic studies of major depressive disorder.
Phenotype integration improves power and preserves specificity in biobank-based genetic studies of major depressive disorder. Nat Genet. 2023 Dec; 55(12):2082-2093.
PMID: 37985818
Applying an evolutionary mismatch framework to understand disease susceptibility.
Applying an evolutionary mismatch framework to understand disease susceptibility. PLoS Biol. 2023 09; 21(9):e3002311.
PMID: 37695771
Evolutionary mismatch and the role of GxE interactions in human disease.
Evolutionary mismatch and the role of GxE interactions in human disease. ArXiv. 2023 Feb 13.
PMID: 36713247
Cross-trait assortative mating is widespread and inflates genetic correlation estimates.
Cross-trait assortative mating is widespread and inflates genetic correlation estimates. Science. 2022 11 18; 378(6621):754-761.
PMID: 36395242
A model and test for coordinated polygenic epistasis in complex traits.
A model and test for coordinated polygenic epistasis in complex traits. Proc Natl Acad Sci U S A. 2021 04 13; 118(15).
PMID: 33833052
Genetic Influences on Disease Subtypes.
Genetic Influences on Disease Subtypes. Annu Rev Genomics Hum Genet. 2020 08 31; 21:413-435.
PMID: 32873077
On the cross-population generalizability of gene expression prediction models.
Keys KL, Mak ACY, White MJ, Eckalbar WL, Dahl AW, Mefford J, Mikhaylova AV, Contreras MG, Elhawary JR, Eng C, Hu D, Huntsman S, Oh SS, Salazar S, Lenoir MA, Ye JC, Thornton TA, Zaitlen N, Burchard EG, Gignoux CR. On the cross-population generalizability of gene expression prediction models. PLoS Genet. 2020 08; 16(8):e1008927.
PMID: 32797036
On Negative Heritability and Negative Estimates of Heritability.
On Negative Heritability and Negative Estimates of Heritability. Genetics. 2020 06; 215(2):343-357.
PMID: 32291292
Clarendon Scholarship
Oxford
2012 - 2016
Phi Beta Kappa
UChicago
2012