Endocrinology, Diabetes and Metabolism

UChicago RECORE

Research for Excellence in Cardiometabolic, Obesity, and Reward-related Conditions

Overview

The UChicago RECORE Center is a collaborative research hub advancing the science and care of obesity, cardiometabolic disease, and related conditions.
We unite experts in endocrinology, obesity medicine, cardiology, electrophysiology, oncology, and psychiatry to explore the impact of anti-obesity medications on metabolic disease, cardiovascular outcomes, atrial fibrillation, addiction, and cancer.

Our mission is to accelerate clinical research by providing a central platform where providers, patients, and community partners can easily find and join active studies. Each trial is listed with a brief description and contact information to simplify referrals and participation.

Through partnerships across the University of Chicago and outreach to community organizations, we aim to expand access, raise awareness, and foster engagement in research that transforms lives

 

Meet the RECORE Team

andrew

Andrew Beaser, MD

Dr. Andrew Beaser, MD, specializes in cardiac electrophysiology, which is the diagnosis and management of heart rhythm disorders. He also specializes in device management for patients who need pacemakers and defibrillators to regulate their heart rhythm.

pannain

Silvana Pannain, MD

Associate Professor of Medicine

Dr. Pannain, Associate Professor and Vice-President of the Illinois Obesity Society, directs Obesity Medicine, leads weight loss trials, investigates disease-modifying effects of anti-obesity medications, and advances public health policies in MASLD/MASH.

casey

Casey Droske

Casey Droske is a Clinical Research Coordinator II and has been with the University of Chicago since 2021. She has a Bachelor of Science in Chemistry and Psychology and experience in behavioral randomized control trials.

Kie Mun Ng

Kie Mun Ng is a Clinical Research Coordinator with experience as a cGMP lab technician and research technologist, passionate about patient safety, regulatory compliance, and the ethical conduct of clinical trials.

shahram

Shahram Sarrafi

Shahram Sarrafi is a senior clinical research coordinator. He earned his master's degree from Rush University Medical College - Division of Translational Science, and he is also ECFMG certified. His research focuses on cardiac arrhythmias.

Stephanie Sintetas

elbert

Elbert S. Huang, MD MPH FACP

Dr. Huang is an international leader in the care of diabetes in older adults. His research has reshaped contemporary geriatric guidelines that emphasize personalized diabetes treatment, management of geriatric conditions, and hypoglycemia prevention.

megan

Megan Huisingh-Scheetz, MD MPH AGSF FGSA

Megan Huisingh-Scheetz, MD, MPH, AGSF, FGSA is a geriatrician and clinical researcher who studies the use of technology to advance frailty assessment and management and in conducting trials in frail older adults. 

pannain

Silvana Pannain, MD

Dr. Pannain, Associate Professor and Vice-President of the Illinois Obesity Society, directs Obesity Medicine, leads weight loss trials, investigates disease-modifying effects of anti-obesity medications, and advances public health policies in MASLD/MASH.

casey

Casey Droske

Casey Droske is a Clinical Research Coordinator II and has been with the University of Chicago since 2021. She has a Bachelor of Science in Chemistry and Psychology and experience in behavioral randomized control trials.

kanoon

Jacqueline Kanoon, MBA, MPH

Jacqueline Kanoon, MBA, MPH manages Dr. Huang’s research in older adults with type 2 diabetes, including trial design, implementation, regulatory submissions, presentations and publications.

erin

Erin Hanlon, PhD

Erin C. Hanlon, Ph.D. is a behavioral neuroscientist - primary research interests have included the detrimental effects of sleep loss and how sleep benefits health, with particular focus on the links between sleep deficiency, obesity, and diabetes.

lee

Kenneth Lee, MD

Dr. Kenneth Lee is a neurologist specializing in sleep medicine and clinical medical director of the UChicago Sleep Center, focusing on sleep disorders like obstructive sleep apnea and narcolepsy and links between sleep and metabolic health.

pannain

Silvana Pannain, MD

Dr. Pannain, Associate Professor and Vice-President of the Illinois Obesity Society, directs Obesity Medicine, leads weight loss trials, investigates disease-modifying effects of anti-obesity medications, and advances public health policies in MASLD/MASH.

Stephanie Sintetas

daniel

Daniel Fridberg, PhD

Dr. Fridberg studies individual differences influencing alcohol and tobacco use. Funded by the National Institutes of Health, his work investigates whether anti-obesity GLP-1 receptor agonist drugs can aid in reducing tobacco and alcohol consumption.

jon

Jon Grant, MD

Jon E. Grant directs a clinic and research lab on addictive, compulsive and impulsive disorders. Professor Grant is the author of over 500 peer-reviewed scientific articles, 15 books, and his research has been supported by NIMH and NIDA.

pannain

Silvana Pannain, MD

Dr. Pannain, Associate Professor and Vice-President of the Illinois Obesity Society, directs Obesity Medicine, leads weight loss trials, investigates disease-modifying effects of anti-obesity medications, and advances public health policies in MASLD/MASH.

laurie

Laurie Avila

Laurie is a Clinical Research Coordinator for the Addictive, Compulsive, and Impulsive Disorders (ACID) Lab, where she helps manage various clinical trials under the direction of Dr. Jon E. Grant.

claire

Claire Wellendorf

Claire Wellendorf is a Lab Coordinator working under Dr. King to investigate the potential for GLP-1 RAs to alter reward-related behaviors, specifically alcohol and tobacco consumption.

christine

Christine Bestvina, MD

Dr. Bestvina is a thoracic oncologist at the UChicago. She leads multiple lung cancer clinical trials focused on immunotherapy-radiation synergy and has contributed to early drug development in targeted therapies for non-small and small cell lung cancer.

marina

Marina Chiara Garassino, MD

Dr. Marina Garassino leads the thoracic oncology program. An international leader in immuno-oncology and precision medicine, she has advanced thoracic malignancy research, authored 340+ publications, and shaped global oncology initiatives.

pannain

Silvana Pannain, MD

Dr. Pannain, Associate Professor and Vice-President of the Illinois Obesity Society, directs Obesity Medicine, leads weight loss trials, investigates disease-modifying effects of anti-obesity medications, and advances public health policies in MASLD/MASH.

🧬 Active & Recruiting Studies

MARITIME-CV Trial

IRB: CIRB25-1173 | Study ID: 20220196
Full Title: A Phase 3 Randomized, Double-blind, Placebo-controlled Study to Evaluate the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants with Atherosclerotic Cardiovascular Disease and Overweight or Obesity (MARITIME-CV)
Link to clinicaltrials.gov
Main Contact: Stephanie Sintetas | ssintetas@bsd.uchicago.edu

SEMINAL-AF Trial

IRB: 23-0889
Full Title: Semaglutide for Metabolic Intervention and Adipose Loss to Treat Atrial Fibrillation
Link to clinicaltrials.gov
Main Contact: Casey Droskey | seminalaf@bsd.uchicago.edu 

------------------------------------------------------------------------------------------------------

✅ Completed Recruitment

GSBR-1290-06 Study

IRB: 24-1458
Full Title: A Phase 2b, Randomized, Double-blind, Placebo-controlled, Dose-range Finding Study of the Efficacy and Safety of Multiple Doses of GSBR-1290 in Participants Living with Obesity (BMI ≥ 30 kg/m²) or Overweight (BMI ≥ 27 kg/m²) with at Least One Weight-related Comorbidity
Link to clinicaltrials.gov
Main Contact: Stephanie Sintetas | ssintetas@bsd.uchicago.edu

Moona Device Study

IRB: 22-1546
Full Title: Randomized Double-Blind Pilot Study to Examine the Effects of a Localized Body Cooling Technology on Sleep and Metabolism in African Americans with Overweight and Obesity 
Link to clinicaltrials.gov
Main Contact: Stephanie Sintetas | ssintetas@bsd.uchicago.edu 

AMG 133 and Obesity Study

IRB: 22-1799
Full Title: A Phase 2 Randomized, Placebo-controlled, Double-blind, Dose-ranging Study to Evaluate the Efficacy, Safety, and Tolerability of AMG 133 in Adult Subjects with Overweight or Obesity, with or without Type 2 Diabetes Mellitus
Link to clinicaltrials.gov
Main Contact: Dr. Silvana Pannain | spannain@bsd.uchicago.edu 

------------------------------------------------------------------------------------------------------

🧾 Not Yet Recruiting / In Development

Apollo Alcohol Study

IRB: 25-0926
Full Title: A Phase 2, Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial to Evaluate the Efficacy and Safety of APL-18881 for the Treatment of Alcohol Use Disorder (AUD)
Main Contact: Laurie Avila |  laurie.Avila@bsd.uchicago.edu 
Status: Not Yet Recruiting

GLAMOUR Study

IRB: Pending Approval
Full Title: Impact of Tirzepatide on Lorlatinib-associated Weight Gain and Metabolic Derangements in Patients with Non–Small Cell Lung Cancer (NSCLC)
Main Contact: To Be Announced
Status: Pending IRB Approval

Amaze 3 Study

IRB: Pending Approval
Full Title: Efficacy and safety of NNC0487-0111 s.c. once-weekly in participants with overweight or obesity, and obstructive sleep apnoea not treated with positive airway pressure
Main Contact: Stephanie Sintetas | ssintetas@bsd.uchicago.edu 
Status: Pending IRB Approval