Overview

Yoav Gilad, PhD
Yoav Gilad, PhD

Chief, Section of General Internal Medicine

University of Chicago
Department of Medicine

Section Chief’s Welcome

The Section of Genetic Medicine was created over 10 years ago to both build research infrastructure in genetics within the Department of Medicine and to focus translational efforts related to genetics. As a result, the Section of Genetic Medicine is shaping the future of precision medicine with very active and successful research programs focused on the quantitative genetics, systems biology and genomics, and bioinformatics and computational biology. The Section provides extremely valuable collaborations with investigators in the Department of Medicine who are seeking to develop new and more powerful ways to identify genetic risk factors for common, complex disorders with almost immediate clinical application.

About the Section

The Section of Genetic Medicine continues to shape the future of personalized medicine with successful research programs focused on the quantitative genetic and genomic science. The Section provides extremely valuable collaborations with investigators in the Department of Medicine who are seeking to develop new and more powerful ways to identify genetic risk factors for common, complex disorders with almost immediate clinical application.

The Section of Genetic Medicine conducts impactful investigations focused on quantitative genetics, systems biology and genomics, bioinformatics and computational biology. Some highlights from the past year include:

  • Demonstrated that RNA splicing is a primary link between genetic variation and disease ( Li, Gilad, et al, Science , 2016)
  • Developed multi-tissue imputation methods to impute gene expression in uncollected or inaccessible tissues to enhance the identification of biomarkers for complex diseases and traits and facilitate the development of precision medicine (Wang, Stranger, Im, Nicolae, et al, American Journal of Human Genetics, 2016)
  • Developed a gene based association method for known and new genes associated with disease traits and provided insights into the mechanism of these associations (Im et al, Nature Genetics, 2015)
  • Developed a new gene based association method for mapping traits using reference transcriptome data that detected known and new genes associated with disease traits and provided insights into the mechanism of these associations. (Im, Nicolae, GTEx Consortium, et al, Nature Genetics, 2015)