Arlene Chapman,MD, Professor of Medicine and Chief of the Section of Nephrology, has been awarded the International Society of Nephrology’s ( ISN) 2020 Lillian Jean Kaplan International Prize for for Advancement in the Understanding of Polycystic Kidney Disease (PKD). The Lillian Jean Kaplan Prize is the most prestigious award for a clinician or clinician scientist working in the area of autosomal dominant polycystic kidney disease.
Dr. Chapman has worked in the field of autosomal dominant polycystic kidney disease (ADPKD) for over 30 years. She established the role of the renin-angiotensin-aldosterone system in hypertension and the increased incidence of asymptomatic intracranial aneurysms (5.5%) in ADPKD. She led efforts to develop an FDA-approved prognostic imaging biomarker (MR-based total kidney volume) in the CRISP study. TKV measurement of cyst burden has led to new treatments including rigorous blood pressure control (the HALT PKD trial) and vasopressin V2 antagonist therapy (the TEMPO trials) where inhibition of the vasopressin V2 receptor slows disease progression. Her efforts have resulted in worldwide approval for the first disease modifying therapy for ADPKD.
With continuous NIH funding for over 20 years, she has led the PKD Foundation as Chair of the Scientific Advisory Committee, creating new funding mechanisms for fellowships and establishing the FASEB research conference in PKD, now in its 15th year.
The Lillian Jean Kaplan International Prize recognizes individual(s) exhibiting excellence and leadership in PKD clinical or basic research and whose seminal scientific work constitutes tangible achievement toward improving knowledge and treatment of PKD. The $50,000 cash prize is one of the most significant awards in the medical research field. Created in 2002, The Lillian Jean Kaplan International PKD Prize was established by the PKD Foundation (USA) and ISN through the generosity of Thomas and Dafna Kaplan of New York, USA, in memory of Mr. Kaplan’s mother, Lillian Jean Kaplan, who was a PKD sufferer and died in 2002.
Dr. Chapman will receive her award at the WCN’21 in Montreal, QC, Canada in April 2021.
To view ISN’s announcement click here: https://www.theisn.org/news/item/3544-join-isn-in-congratulating-the-recipients-of-isn-2020-awards